Join Massimo Mangiola, Ph.D., A(ACHI) Immunogenetics Laboratory Director at NYU Langone Transplant Institute to learn more about PIRCHE and how it can help you see beyond limits of transplant diagnostics.

Description: Understand the Clinical relevance of NK (natural killer) cells Immunogenetics

Speaker: Dr. Rajalingam Raja, UCSF, USA

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Description: 

Shared case studies are a learning opportunity for all! Our subject matter experts will be reviewing HLA antibody analysis on the NEW MATCH IT! Antibody v1.5 software using informative case studies and software tools!

Effect of HLA Class I Signal Peptide variation on HLA-E Expression with Dr. Mary Carrington, Center for Cancer Research, Bethesda, ML

Course Objectives:

• Nomenclature
• HLAi & UKLKSS
• Allocation
• Post-transplant

Speaker: Miriam Manook, MBChB, MRCS (Ed), PhD

Webinar Objectives:

This seminar is aimed at Transfusion Practitioners, Transfusion Laboratory Teams and Transfusion Consultants keen to better understand the needs of this special patient group, neonates.

Speaker: Martha Sola-Visner. MD.

Webinar Objectives:
• Organize and categorize transfusion complications given the reported signs and symptoms.
• Discover how laboratory findings correlate with the clinical signs and symptoms of transfusion complications.
• Compare and contrast acute and delayed transfusion reactions.
• Apply how to define the adverse complications of transfusion in example case studies.

Summary of Session:
Transfusion complications are a risk of the transfusion of blood. Response to transfusion may be defined acute or delayed, hemolytic or non-hemolytic and immune or non-immune. This course will define categories of transfusion reactions, with applicable clinical response and laboratory investigation. Resolving the type of reaction and appropriate recommendations for further transfusions will be explored

Speaker: Jayanna Slayten, MS, MT(ASCP)SBB^CM

Webinar Objectives:
• Distinguish immune response into the action of T Cells and B Cells.
• Recognize the role of immunoglobulins and cells involved in primary and secondary immune response.
• Outline function and process of complement activation in transfusion medicine.
• Demonstrate genetic concepts of blood groups exploring pedigree analysis and population genetics.

Summary of Session:
The field of Immunohematology is built on immunology, complement and genetics. This course will explore immune response and how antigen-antibody defines serologic blood bank testing. Factors which influence antigen and antibody binding with the activation of complement will be defined. As antigens are defined, the genetics of the expression will be clarified. Genetic expression with applicable population genetics and pedigree analysis will be correlated with blood group expression. This course is a starting point for a deeper understanding of the foundations of Blood Banking and Transfusion Medicine.

Speaker: Jayanna Slayten, MS, MT(ASCP)SBB^CM

Webinar Objectives:
• Identify the common blood groups by genetic background, antigen, antibody and clinical significance.
• Discriminate uncommon blood groups by genetic background, antigen, antibody and clinical significance.
• Give examples of unique characteristics of blood groups and how they relate to the clinical outcomes in patients.
• Apply the knowledge of blood groups to provide the most appropriate blood products for transfusion.

Summary of Session:
This course is a comprehensive review of all blood groups both common and uncommon. Each blood group will be
defined by its antigen and antibody with emphasis on clinical significance or insignificance. Unique characteristics
and clinical correlation for specific blood groups will be highlighted. Resources for further and in-depth study of the
blood groups will be highlighted for the participant.

Speaker: Jayanna Slayten, MS, MT(ASCP)SBB^CM

Webinar Objectives:
• Appraise the value of common serologic blood bank methods for the resolution
of serologic blood bank challenges.
• Categorize the methods and tools for atypical serum/plasma challenges compared to red cells challenges.
• Define a systematic approach for ABO discrepancies and atypical antibody detection findings.
• Employ serologic methods in case study examples to demonstrate efficient application.

Summary of Session:
Serologic problem solving in the Blood Bank can be mastered by understanding and implementing the right tool at
the right time. This course will define the advantages and disadvantages of common blood bank methods. Tools
to resolve ABO discrepancies and atypical antibody detection findings will be explored. Mastering these tools will
improve overall serologic problem solving allowing for these challenges to be resolved efficiently.

Speaker:  Jayanna Slayten, MS, MT(ASCP)SBB^CM

Webinar Objectives:
• Define normal and abnormal coagulation lab findings.
• Correlate laboratory results with common clinical signs and symptoms in the patient.
• Discriminate normal and abnormal platelet laboratory results.
• Apply coagulation and hematology results in case study examples focusing on the provision of appropriate
transfusion of blood products or medical intervention.

Summary of Session:
The ability to maintain hemostasis is monitored in the laboratory with coagulation and hematology methods. This course will define the laboratory methods and analysis used in the evaluation of the overall hemostasis of a patient. Discussion will include maintaining normal hemostasis and what actions may occur with abnormal hemostatic findings. The Blood Bank/Transfusion Service aid in the care of the patient with abnormal hemostatic or platelet results with the provision of timely blood administration.

Speaker: Jayanna Slayten, MS, MT(ASCP)SBB^CM

Webinar Objectives: 

• Clear and Unambiguous Typing Results: MIA FORA NGS Expanded Coverage
• Anti-HLA Antibody Strength & Crossmatch: Is there a Correlation?
• Enhancing Antibody Analysis for the Benefit of Patient Outcomes using PIRCHE Technology
• Where Do We Go from Here? The Present and Future of Non-HLA.

Speakers:

Tiffany K Bratton, PhD, DABCC, FAACC, FACHI

Alin Girnita, MD, PhD, D(ACHI)

Bethany L. Dale, PhD

Michelle Hickey, PhD, D(ACHI)

Webinar Objectives:
• Explain detection and identification of red cell alloantibodies.
• Explore problem solving techniques including evaluation of the patient’s clinical and transfusion history, autocontrol, DAT and red cell phenotype.
• Define appropriate testing methods for IgM compared to IgG reactive antibodies.
• Apply antibody identification practices in case studies

Summary of Session:
When the antibody detection test is reactive and antibody identification is required. This course will define the common rules, requirements, and rigors of identification of red cell alloantibodies. Finding a pattern of reactivity is one step in defining the specificity of antibody reactivity. Responding with patience and precision for next steps in antibody identification will be demonstrated in case study examples.

Speaker: Jayanna Slayten, MS, MT(ASCP)SBB^CM

validação e conduta nas transfusões de plaquetas; Crossmatching plaquetário; Refratariedade Plaquetária.

Speakers: Ana Paula Rocha Diniz Zanelli; Cristina Altobeli; Juliana Pires Marafon Franz

Reagentes Especiais em Imunohematologia: como usar e qual a importância na resolução de casos clínicos complexos; A importância da detecção sorológica para direcionar a investigação molecular; Tipagem molecular dos genes de grupos sanguíneos no auxílio diagnostico.

Speakers: Regina Cardoso; Tatiane de Paula Vendrame; Carine Arnoni, Tamires Delfino dos Santos, Lilian Castilho, PhD

Level of Instruction: Basic

Summary of Session:  The second webinar in this BBTS series invites Noemi Roy to talk about advances in treatments for patients with Sickle Cell Disease. Noemi will be followed by Farrukh Shah, who will talk about the National Haemoglobinopathy Registry

Speakers:

Noemi Roy

Consultant Haematology

Oxford University Hospitals NHS Foundation Trust

Farrukh Shah

Medical Director, Transfusion at NHSBT

Consultant, Whittington Health NHS Trust

Session will be chaired by Julie Staves, Chair of BBTS Annual Meeting Committee

Chairperson:

Dr. Anand Deshpande, Consultant Transfusion Medicine & Haematology,

P. D. Hinduja National Hospital & M. R. C. Mahim, Mumbai

Speaker:

Dr. Rajeshwari Basavanna, Consultant Transfusion Medicine,

P. D. Hinduja National Hospital & Medical Research Centre,

Mumbai, Maharashtra, India.

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Summary of Webinar:

With over 70% of the UK’s air ambulance charities now carrying blood on board, the introduction of pre hospital blood transfusion has improved the chances of survival in the most critically ill and injured patients.

This webinar invites Dr James Raitt to share guidance and governance around pre hospital transfusions, the logistics and mechanics of providing blood on board and a recent review of patients who were transfused in the pre hospital setting. Kerry Dowling will talk on continued evolutions in pre hospital transfusion, discussing the use of O pos red cells in the emergency roadside setting.

AGENDA

Blood component usage in the pre hospital setting

Dr. James Raitt MBChB, FRCEM, FIMC

Consultant in Emergency Medicine and Pre Hospital Emergency Medicine

Audit, Improvement and Research (AIR) Group Lead

Thames Valley Air Ambulance

The use of O positive red cells in the pre hospital setting

Kerry Dowling

Blood Transfusion Laboratory & Phlebotomy Manager

Laboratory Medicine

Southampton General Hospital

Session will be chaired by Julie Staves, Chair of BBTS Annual Meeting Committee

Speaker:

Dr. Joannis Mytilineos

Chief Medical Officer, ZKRD,

German National Bone Marrow Donor Registry

Speaker: Dr. Meenakshi Singh, Advanced center for Treatment, Research and Education in Cancer, Navi Mumbai, India

The aim of this symposium is to present some case studies in different immunohematology segments that require the use of advanced serologic or genomic procedures.

AGENDA

RhD Case Studies: Interpretation and Patient Risks in Transfusions
Dr Lilian Castilho, PhD
Director of the Molecular Immunohematology Laboratory
at Hemocentro-UNICAMP-Campinas, Brazil

Management of platelet alloimmunization on the Maternity Laboratory
Dr Rachel Petermann, MD, PhD
Centre National de Référence d’Hémobiologie Périnatale UF Biologie CNRHP –
Immunologie plaquettaire Hôpital St Antoine, France

The challenging effects of monoclonal antibody therapies on the Transfusion Laboratory
Julie Staves Manager, Transfusion Laboratory
Oxford University Hospitals NHS Trust, United Kingdom