ATS-13 is a quantitative assay for the measurement of ADAMTS-13 enzyme activity in human plasma using FRET technology. Fluorescence resonance energy transfer (FRET) is a distance-dependent interaction between the electronic excited states of two molecules in which excitation is transferred from a donor molecule to an acceptor molecule without emission of a photon.
ATS-13 Activity Assay is a quantitative assay for the measurement of ADAMTS-13 enzyme activity using FRET technology. A large body of literature shows that ADAMTS-13 is the protease responsible for cleaving von Willebrand Factor. Significant decreases or an absence of ADAMTS-13 activity can lead to the formation of ultra-large vWF fragments. Antibodies against ADAMTS-13 have also been shown to cause a decrease in ADAMTS-13 activity.1
ATS-13 Activity Assay offers the following benefits:
- Easy: Assay set-up in less than 10 minutes
- Fast: Results in under 45 minutes
- Sensitive: Fluorescent endpoint