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PreciseTypeTM HEA (human erythrocyte antigen) - NEW Test of Record for Extended Blood Cell Antigen Typing.

The first and only FDA-approved in-vitro diagnostic (IVD) for molecular typing of red blood cell antigens

PreciseType™ HEA test is a multiplexed molecular assay that generates detailed molecular information from patient and donor samples, rapidly detecting genotypes for accurate prediction of phenotypes:
  • Tests for a wide range of genetic variants affecting red blood cell antigen expression1
    • Automated array imaging
    • Computerized data management
  • Identifies the most relevant 35 red blood cell antigens from 11 blood groups

Clinicians

Raising the Standard of Care: Advantages of Molecular Technology

Knowledge is power 


 

Multiply-transfused patients are at increased risk of developing hemolytic reactions and alloimmunization — a serious problem with lifelong consequences.4 The risk is also elevated for multiparous women, who are more likely to develop antibodies from contact with fetal blood.6–8


Test results can be applied to a number of clinical situations

PreciseTypeTM HEA test generates detailed molecular information from patient and donor samples, rapidly detecting genotypes for accurate prediction of phenotypes. By providing more detailed and specific information regarding clinically relevant antigens faster than is possible with serology, PreciseTypeTM HEA test results can be applied to a number of clinical situations, and it may enhance patient care in certain situations, including4:

  • Recently transfused patients
  • Patients with autoantibodies
  • Chronically transfused patients
  • Patients with:
    • SCD
    • Thalassemia
    • Autoimmune hemolytic anemia
  • Prenatal testing:
    • Genotype fetal DNA to predict risk for HDFN

For some users, data from PreciseType™ HEA Tests will also enable the creation of a detailed database containing antibody and molecular antigen typing information.

For additional information on pay or coverage, please call 855.466.8267 or contact your local Molecular and Specialty Diagnostics Business Manager.



Patients and Family

With health conditions that require frequent transfusions, patients and their families depend on a close match between donors and recipients. Compatibility helps to ensure that transfusion reactions and other, potentially serious, problems can be avoided.

PreciseTypeTM HEA provides doctors with highly detailed, genetic information about blood so they can make better matches between donors and recipients. Information from this test helps prevent mismatches that can cause potentially life-threatening reactions.

Find out how molecular antigen testing – which uses the genetic information from whole blood to increase the probability of transfusion compatibility – can provide benefits in a variety of medical conditions and situations.
www.PersonallyPrecise.com



References

  1. PreciseTypeTM HEA Test Package Insert.
  2. Westhoff CM. Molecular testing for transfusion medicine. Curr Opin Hematol. 2006;13:471–475.
  3. Kochman SA. Role of the Food and Drug Administration in the use of molecular techniques in immunohematology. Transfusion. 2007;47(1 Suppl):3S–9S.
  4. Hillyer CD, Shaz BH, Winkler AM, Reid M. Integrating molecular technologies for red blood cell typing and compatibility testing into blood centers and transfusion services. Transfus Med Rev. 2008;22:117–132.
  5. Karpasitou K, Drago F, Crespiatico L et al. Blood group genotyping for Jk(a)/Jk(b), Fy(a)/Fy(b), S/s, K/k, Kp(a)/Kp(b), Js(a)/Js(b), Co(a)/Co(b), and Lu(a)/Lu(b) with microarray beads. Transfusion. 2008;48:505–512.
  6. Blumberg N, Peck K, Ross K, Avila E. Immune response to chronic red blood cell transfusion. Vox Sanguinis. 1983;44:212–217.
  7. Shirey RS, Boyd JS, Parwani AV, Tanz WS, Ness PM, King KE. Prophylactic antigen-matched donor blood for patients with warm autoantibodies: an algorithm for transfusion management. Transfusion. 2002;42:1435–1441.
  8. Issitt PD, Combs MR, Bumgarner DJ, Allen J, Kirkland A, Melroy-Carawan H. Studies of antibodies in the sera of patients who have made red cell autoantibodies. Transfusion. 1996;36:481–486.